ZIKA VÍRUS - BRASIL (13) (CEARÁ), PRIMATAS NÃO-HUMANOS, ABSTRACT
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Data: Sábado, 23 de abril de 2016
Fonte: Biorxiv [20/04/2016] [editado]
<http://biorxiv.org/content/biorxiv/early/2016/04/20/049395.full.pdf>
First detection of Zika virus in neotropical primates in Brazil: a
possible new reservoir
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Silvana Favoretto, Danielle Araújo, Danielle Oliveira, Nayle Duarte,
Flavio Mesquita, Paolo Zanotto, Edison Durigon
In Brazil, the first diagnosed case of Zika virus (ZIKV) in humans was
reported in 2015 in Rio Grande do Norte State in the Northeast region,
with subsequent reports in 22 States of the Country (1).
We tested samples from sera and oral swabs from fifteen marmosets
(Callithrix jacchus) and nine capuchin-monkeys (_Sapajus libidinosus_)
captured (SISbio license 45196-3) from July to November of 2015 in
Ceará State, an epidemic area for ZIKV. Preliminary detection of
these samples indicated 29% of positivity (7/24) by Real time PCR (2)
(Cycle Threshold Ct average 31,64 to 37,78).
We found four positive samples from marmosets and three positive
samples from capuchin monkeys. To further validate the Real time PCR
we sequenced the amplified product from one capuchin monkey and one
marmoset, and found that it had ZIKV with 100% similarity to other
ZIKV from South America (Table 1 [veja em
<http://biorxiv.org/content/biorxiv/early/2016/04/20/049395.full.pdf>
- Mod. RNA]).
Primates were captured at several, far apart regions of the State,
including coastal, savannah (caatinga biome) and a mountain range with
rainforest remnants. It is noteworthy that marmosets were free
ranging, co-inhabiting with humans; the capuchins were pets except for
one that was kept in a screening center for wild animals in Fortaleza
(capital of the State and coastal region).
After sample collection, they were tagged with microchips and released
back to their original site. Currently, Brazil is facing a massive
ZIKV epidemic, associated with severe neuropathy. Three hundred and
sixty three cases of microcephaly were notified in Ceará alone in the
period from October 2015 to March 2016. Out of these, seventy (19·3%)
had laboratory confirmation to related to ZIKV infections (3).
Crucially, cases of microcephaly occurred in municipalities from where
viremic monkeys were sampled (Figure 1 [veja em
<http://biorxiv.org/content/biorxiv/early/2016/04/20/049395.full.pdf>
- Mod. RNA]). This is the first report on ZIKV detection among
Neotropical primates, which stands as a caveat for the possibility
that they could act as reservoirs, similar to the sylvatic cycle of
yellow fever in Brazil (4).
-
References
--
1. Brazil, Ministry of Health. Monitoring of cases of dengue,
chikungunya and zika virus fever to the epidemiologic week five, 2016.
Boletim epidemiológico N.8, 47, 2016.
<http://portalsaude.saude.gov.br/images/pdf/2016/fevereiro/29/2016-006>
--- Dengue-SE5-publica----o.pdf. (Accessed 09/03/2016).
2. Lanciotti RS, Kosoy OL, Laven JJ et al. Genetic and serologic
properties of Zika virus associated with an epidemic, Yap State,
Micronesia, 2007. Emerg Infect Dis. 2008; 14(8):1232-9.
3. Ceará, State Health Department. Epidemiologic report: microcephaly
and CNS malformations. March 07 2016.
<http://www.saude.ce.gov.br/index.php/boletins>. (Accessed in
09/03/2016).
4. Brazil, Ministry of Health. Surveillance guide for epizootics in
non-human primates and applied entomology for yellow fever
surveillance. 2 ed -Brasília: Ministry of Health, 2014.
<http://bvsms.saude.gov.br/bvs/publicacoes/guia_vigilancia_epizootias_primatas
_entomologia.pdf>.
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[Veja post e comentário anterior [PRO/PORT> Zika vírus - Brasil (12)
(CE), primatas não-humanos Archive Number:
http://promedmail.org/post/20160423.4178844,
<http://promedmail.org/post/4178844>].
- Mod. RNA]
[Veja também:
Zika vírus - Brasil (12) (CE), primatas não-humanos Archive Number:
http://promedmail.org/post/20160423.4178844
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